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An SGLT2 inhibitor with demonstrated evidence of benefit is recommended for individuals with HF with reduced ejection fraction [61,62] or HF with preserved ejection fraction [63,64] [Grade A, Level 1A for dapagliflozin or empagliflozin]
Beyond that, the evidence is per-compound plus the CagriSema (cag + sema) Phase 3 data as the closest human analog
Medications remain HSA/FSA eligible, and the transparent monthly pricing eliminates surprise out-of-pocket costs that often accompany insurance-based coverage
These criteria are more stringent than the previous Rotterdam criteria, aiming to identify women with higher metabolic risks associated with PCOS (131)
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